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Supridol (Tramadol)

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Supridol is a centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. Supridol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine.

Other names for this medication:
Anazac, Bludol, Bramadol, Contradoc, Decotram, Dolocet, Dolotram, Domadol, Eltram, Gemodol, Ivydol, Madol, Medol, Moludol, Mydol, Nopidol, Novadol, Ondol, Orchidol, Oshdol, Paintrol, Pentazen, Postadol, Stemadol, Supridol, Tamody, Tandam, Topspas, Traceta, Tragesic, Traiz, Tramagesic, Tramalex, Tramasol, Tramataur, Tramol, Trampar, Tranat, Trandy, Transic, Trapidol, Trugesic, Ubitdol, Vardol, Vintram, Xidol, Xtram

Similar Products:
Minipress, Calan, Rebetol, Chloromycetin, Dramamine, Xenical, Feldene, Exelon, Kefurox, Fenamon, Cilazil, Ozopride, Alapren, Lipizim, Giardyl,

Also known as: Tramadol


Supridol ER is an pain medicine similar to an opioid. This medicine is used to treat moderate to severe pain.

The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Supridol: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Supridol is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Supridol dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Supridol Lyophilized dosage information

Side effects

The most common side effects associated with Supridol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how Supridol ER will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

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Perinatal exposure to di-(2-ethylhexyl) phthalate affects anxiety- and depression-like behaviors in mice. This was reflected by changes in cardiac reactivity driven by differences in sympathetic-adrenal-medullar and hypothalamic-pituitary-adrenal axis activation. Patients with MCA infarction showed not only delayed swallowing onset and pretrigger duration, but also shorter duration of sEMG activity compared with those in healthy volunteers. We show that both chromosomal proteins and DNA are tritium-labelled. Nasoendoscopic findings after primary palatal surgery: can the Furlow technique result in a smaller velopharyngeal gap?. Early clinical results indicate that colour Doppler sonography is able, at the same time, to demonstrate morphology and function (direction flow and flow velocity) of significant vascular abnormalities by a non-invasive method.

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Transplacental clearance and blood flows of bovine gravid uterus at several stages of gestation. In the present study we examined the effect of acute immunosuppression induced by total body irradiation (TBI) (900 to 1100 centigray (cGy)) or by a single high dose of cyclophosphamide (CY) (300 mg/kg), followed by syngeneic bone marrow transplantation (SBMT), on the development of EAE in SJL/J mice. The usefulness of age and sex to predict all-cause mortality in patients with dilated cardiomyopathy: a single-center cohort study. Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) often coexist in older adults. Treatment of infectious hepatitis in children with corticosteroids. Fast electrophoresis of DNA fragments in miniature agarose slab gels allowed rapid and unequivocal identification of the MAV strains.

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Specimens from a human temporal bone repository were investigated for clinical or otopathologic evidence of occult bony dehiscence indicating communication between the subarachnoid space and air cells of the temporal bone. The development of antibodies in the cotton rats transplanted with the adult cotton rat filaria, Litomosoides carinii. THE ACTION OF PH AND OF BACTERIAL DENSITY ON THE ACTIVITY OF 16 ANTIBIOTICS IN SENSITIVITY TESTS. A real data set is analyzed to illustrate the application of the new sampling distribution for incomplete contingency tables and the analysis results again confirm the conclusions obtained from the simulation studies. Exogenous addition of glutathione and other antioxidants enhanced resistance of Arabidopsis to Tcin while the addition of buthionine sulfoximine, an inhibitor of glutathione synthesis, increased sensitivity, suggesting that resistance was mediated by glutathione. A Novel Single-Nucleotide Deletion (c.1020delA) in NSUN2 Causes Intellectual Disability in an Emirati Child. Inactivation of platelet-activating factor by a putative acetylhydrolase from the gastrointestinal nematode parasite Nippostrongylus brasiliensis.

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Electric properties of enamel and dentin in normal teeth and in fluorosis. Diurnal variations of the prolactin concentration in cattle blood and the influencing by the milking stimulation as well as by oxytocin and estrogen administration. Esthesioneuroblastoma--treatment of recurrences using the remote-control afterloading technic. Although recurrence in a needle track occurs very infrequently, clinicians should be aware of this phenomenon and investigate any changes, particularly when occurring at a needle biopsy site. Gestational Weight Gain Trend and Population Attributable Risks of Adverse Fetal Growth Outcomes in Ohio. Decomposition of the matrix provides an interpretation in terms that are quite familiar.

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Evaluation of the novel three-dimensional porous poly (L-lactic acid)/nano-hydroxyapatite composite scaffold. Physical Growth, Biological Age, and Nutritional Transitions of Adolescents Living at Moderate Altitudes in Peru. Increases in plasma 25(OH)D levels are related to improvements in body composition and blood pressure in middle-aged subjects after a weight loss intervention: Longitudinal study. The aim of this study was to increase our understanding of low treatment-seeking rates among soldiers and veterans by expanding upon previous measurements of the stigma construct and examining factors influencing willingness to seek treatment. Prospective analysis of factors associated with dental behavior management problems, in children aged 7-11 years. Numeric rating score of Group O showed significantly lower than that of Group F during 30 min, 2, 4, 8 and 24 h postoperatively. Three hundred nurses were assigned into study and control groups randomly. Prescribers of high-dose opioids received a mailing (intervention) containing a member-specific letter, medication profile, and satisfaction survey to determine the prescriber-perceived clinical value of the program.

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The systematic approach to ICU cEEG findings presented herein not only resolves the standardization debate but also clarifies clinical reasoning by helping electroencephalographers assign appropriate weights to cEEG findings in the face of uncertainty. Similarly, the exploitation of the most promising enzymatic detoxifying routes designed for trans-ZEN - which relies on the enzyme lactono hydrolase from Clonostachys rosea - has been assessed for the cis-isomer as well. DRS may be useful for real-time objective evaluation of liver steatosis during liver transplantation, especially to differentiate between mild and moderate/severe steatosis. Tolerance is made possible by the production of very high amounts of glucose in liver which is then sent to other organs where it acts as a cryoprotectant. Mutual coevolution of rationally designed HIV vaccine candidates, with affinity maturation pathways of antibodies they induce upon vaccination, may best mimic the natural situation of chronically HIV-infected patients who are able to generate norvasc bp medicine broadly neutralizing antibodies. Cod liver oil significantly blocked all of these except pyruvate carboxylase, fructose 1,6-diphosphatase and glucose 6-phosphatase.

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There is a need for interventions facilitating functioning on a broad level and support toward societal inclusion for individuals with ASD. COURSE OF DISSEMINATED PULMONARY TUBERCULOSIS IN ANTIBACTERIAL TREATMENT. We have compared the 31P nuclear magnetic resonance (NMR) spectra of two different cisplatin resistant cell lines, one derived from human ovarian carcinoma and the other from rat lymphoma, and their respective cisplatin sensitive parental cell lines. Free energy cost of reducing noise while maintaining a high sensitivity. In conclusion, sedentary occupations have higher cardiovascular risk secondary to accelerated atherosclerosis. The two main mechanisms of T2D pathogenesis are pancreatic beta cell dysfunction and insulin resistance.

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In the group of IgG1 myelomas, deficiency was established in the subclasses IgG2-4, in the group of IgA myelomas, deficiency was proved in all IgG1-4 subclasses as compared with non-myeloma paraproteinemias. Exploring mechanisms of resistance to dimethachlone lopressor generic and trade name in Sclerotinia sclerotiorum. The three tryptophan residues in the sequenced peptides align with UGA codons in the nucleotide sequence, indicating that the nonsense codon UGA is used as a tryptophan codon in M. The biotechnological production of proteins is currently achieved via expression systems derived from different lineages. The burden of skeletal-related events in patients with prostate cancer and bone metastasis. The programmed/ non-programmed question is critical to medical research because the theories have grossly different predictions regarding the biological mechanisms associated with the aging process and therefore, the nature of age-related diseases and conditions.

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Pain-Coping Traits of Nontraditional Women Athletes: Relevance to Optimal Treatment and Rehabilitation. Data were analysed focusing on the role of imprisonment, factors associated with awareness of being HIV infected and condom use. Extrinsic aging changes caused by habitual exposure to ultraviolet light are often erroneously confused with intrinsic aging alterations due to chronologic aging. Concentrations of Heavy Metals in Sardinella gibbosa (Bleeker, 1849) from the Coast of Balochistan, Pakistan. From these results it is believed that an elevation of collagenase activity related directly to tissue destruction might be involved, as well as a decrease in the gastric mucosal blood flow, in the etiology of ulcers due to restraint and water immersion stress.

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Conformational plasticity of a native retroviral capsid revealed by x-ray crystallography. Gut and salivary glands were collected from ticks during the 21-d experiment and examined with light and electron microscopy. Histological analysis indicated significantly higher disc degeneration scores in 9-month-old guinea pigs para que sirve arcoxia 90 mg in comparison with younger animals, and grew higher with increasing age. Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Upregulates Ciliary Neurotrophic Factor in Astrocytes and Oligodendrocytes. Using the model of platelet activation, we demonstrate that two different Fc-dependent mAb, LeoA1 and ALB6, both activate the cell by forming intercellular links between Ag on one cell and FcR on the opposing platelet.

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